INCI HydroquinoneEastman Hydroquinone, USP is a skin care ingredient used to produce effective skin- lightening applications for depigmentation. Keywords: D-170D; D-170; D170D; D170 Created Date ORIGINAL CODE: 0009013, Ref document number: New experimental data are provided for the solubility of resorcinol in water and salicylic acid, resorcinol, hydroquinone in 1-octanol. This composition is color stabilized and cosmetically elegant. 57, 295300 (2013), R. F. Pires, M. R. Franco Jr, Fluid Phase Equilib. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25 K to 334.45 K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. The solubility was increased by addition of ethanol, reached a maximum . 0000002379 00000 n : Metabolism and disposition of hydroquinone in Fischer 344 rats after oral or dermal administration. I'd like the consistency to be thin like a gel so that it absorbs quicker. vitamin C; Salts thereof, Medicinal preparations containing active ingredients not provided for in groups A61K31/00-A61K41/00, Mixtures of active ingredients without chemical characterisation, e.g. Retinoids are included from about 0.01% to about 5%, preferably from about 0.025% to about 2%, more preferably 0.05% to about 1.0%, and most preferably from about 0.025% to about 0.5%. Human exposure to hydroquinone can occur by dietary, occupational, and environmental sources. The experimental solubility data was well-correlated with the data, calculated by . Chem. Hydroquinone is used as a topical application in skin whitening to reduce the color of skin. Preparation, optimization and in vivo. Treatment with hydroquinone interferes with the action of tyrosinase, which is an enzyme used in the synthesis of melanin, and compositions are sold across the counter at about 2% hydroquinone and by prescription at higher concentrations. The most preferred example of such an antioxidant is sodium metabisulfite. Cookie Notice uv curable cellulose estersuv curable cellulose esters . . I made my own hydroquinone 4% and added it to my cream. Solubility of Hydroquinone. [31], Hydroquinones are one of the two primary reagents in the defensive glands of bombardier beetles, along with hydrogen peroxide (and perhaps other compounds, depending on the species), which collect in a reservoir. Add the hydroquinone to the water. I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. It can also be found on eBay and Amazon. Antioxidants in the hydroquinone phase are instrumental in stabilizing the color of the hydroquinone composition. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. ;O,1Y+%8#oKT^VWtew4>@V.SR :hmBZ>#ey!UC5! / /n Hydroquinone is 1,4-benzenediol. S.C. Gad, T. Pham, in Encyclopedia of Toxicology (Third Edition), 2014 Environmental Fate and Behavior. Hope it helps 6 yrs later. Some may double boil the hydroquinone and ester, I was too scared of the possibility of combustion. Hydroquinone is an aromatic organic compound which is currently used in two main sectors: . 114, 175188 (1996), I. Hahnenkamp, G. Graubner, J. Gmehling, Int. One skilled in the art is familiar with the known protective system technologies, such as encapsulation and entrapment methodologies. HVoLg~Z+ It does not have the same predisposition to cause dermatitis as metol does. Variations in pH have proven to result in excessive discoloration ranging from brownish to black. Natural antioxidants could replace hydroquinone derivatives used in industry. Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . Data 51, 16681671 (2006), C. L. Yaws, S.-C. Lin, Enthalpy of fusion at freezing pointOrganic compounds, in Thermophysical Properties of Chemicals and Hydrocarbons, William Andrew Publishing (Elsevier, 2009), pp. Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. It is a reducing agent that is reversibly oxidized to semiquinone and quinone. application/pdf The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. Hydroquinone can lose a hydrogen cation from both hydroxyl groups to form a diphenolate ion. [33], Hydroquinone has been shown to be one of the chemical constituents of the natural product propolis. Inhalation Remove to fresh air. Ferulic acid 0.5% 0.15g. As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. Your document download will begin shortly. Find answers in our support articles. Classical photo shops also sell hydroquinone. HYdroquinone can be found in various skin care products. Thermodyn. ChemPoint will not under any circumstances release personal user information to individuals or companies. If you are already a ChemPoint customer then sign up for access to our online ordering website. Heat Mass Transf. J. Pharm. Since the neutral pH of the hydroquinone composition with sodium metabisulfite and magnesium ascorbyl phosphate is preferably from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, the pH is acceptable for also including retinoids in the composition. 0000003430 00000 n Calorim. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. 0000005306 00000 n Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. [Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O, trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane, C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1, C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C, 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine, CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC, 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1, O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C, [Na+].[Na+].[Na+]. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), which are protected have been shown to also be color stable in hydroquinone, magnesium ascorbyl phosphate and sodium metabisulfite composition at about a neutral pH, preferably from about 5.5 to about 8.0, more preferably from about 5.5 to about 7.5, and most preferably from about 6.0 to about 7.5. Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. Such carriers are widely known in the art and deliver the composition's ingredients to the skin without excessive degradation, inactivation or other unwanted interaction. Determination and Correlation of Solubilities of Benzoic Acid, Salicylic Acid, Resorcinol and Hydroquinone in Water and in 1-Octanol at Temperatures from 297.25K to 334.45K. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Tests, which results are detailed in the following two tables, are performed to show how well sodium metabisulfite ("SMBS") stabilizes color at each pH at 5C and 40C in 4% hydroquinone ("HQ") compositions. This website uses cookies. An acceptable carrier also possesses suitable aesthetic and cosmetic qualities and may include emollients, conditioners and the like. n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. [34], It is also one of the chemical compounds found in castoreum. 0000004197 00000 n Bioaccumulative potential Hydroquinone (123 -31 -9) Bioaccumulative potential Not established. Canon I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. 0.5% magnesium ascorbyl phosphate protected at pH 6.0-7.0, 1.0-1.5% at pH 5.5-7.0, and 2.0-3.0% at pH 3.5-7.0. Discoloration of hydroquinone compositions may be accelerated by repeated exposure to oxygen or exposing the compositions to high temperatures, which may be found inside a car or delivery vehicle on a hot sunny day. Hydroquinone (C6H4(OH)2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. volume42, Articlenumber:1 (2021) Please sign in to view account pricing and product availability. Have an order or account question, find answers in our Online Support articles. 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. Recent pieces of . The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. For a shipping quote, check the box and the bottom and provide us your shipping information. Hydroquinone is a white, odorless, crystalline solid with an extremely low vapor pressure. Eng. Hydroquinone can be made through several routes. uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. Antioxidants, preferably sulfites, including but not limited to sulfites, bisulfites, metabisulfites, their salts, and their derivatives, most preferably sodium metabisulfite, have been used to stabilize certain compositions, which have included hydroquinone. 0000002221 00000 n The method of item 1 07 wherein the hydroquinone is present in about 4%. I would like to add retinol and kojic acid to it as well. The process of making a stable hydroquinone composition having a pH of about 5.5 to about 8.0 comprising: combining the following ingredients, in a carbon dioxide atmosphere: first, magnesium ascorbyl phosphate and sodium metabisulfite, then, third, magnesium ascorbyl phosphate, then, Application filed by Medicis Pharmaceutical Corp, [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O*, OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C, 3-aminopropyl [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] hydrogen phosphate, NCCCOP(O)(=O)OC1=C(O)[C@@H]([C@@H](O)CO)OC1=O, OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, OC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C, trisodium;[(5R)-5-[(1S)-1,2-dihydroxyethyl]-2-oxido-4-oxofuran-3-yl] phosphate, [Na+].[Na+]. Toxicol. The preferred form of protected retinol is manufactured by SunSmart (also known as Particle Sciences, Inc. of Bethlehem, PA) under the brand name of SunCaps A-1283. 420, 2429 (2016), W. E. Acree Jr, Thermochim Acta 189, 3756 (1991), F. L. Nordstrm, . C. Rasmuson, J. Chem. Hydrogen peroxide is used and the reaction gives a mixture of hydroquinone and catechol: An accessible route involves the reaction of sodium hydroxide with 1,4-dichlorobenzene. Part of Springer Nature. 330, 4851 (2012), A. Shalmashi, A. Eliassi, J. Chem. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. [27] Several such agents are already available or under research,[28] including azelaic acid,[29] kojic acid, retinoids, cysteamine,[30] topical steroids, glycolic acid, and other substances. For more information, please see our This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. M1 and M2 microemulsions contain ethanol as co-surfactant. Hydroquinone occurs as fine, white needles. 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. Thanks to the added vitamin E, it leaves your skin feeling smooth and soft, too. Hydroquinone | C6H4(OH)2 or C6H6O2 | CID 785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. Hydroquinone Safety Data Sheet according to Federal Register / Vol. 0000008435 00000 n 374 0 obj << /Linearized 1 /O 376 /H [ 807 1414 ] /L 581425 /E 96582 /N 109 /T 573826 >> endobj xref 374 19 0000000016 00000 n Hydroquinone, like phenols are very weak acids and can be deprotonated. The color stability of the hydroquinone composition is promoted by one or more antioxidants in the hydroquinone phase, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate. Phase A is added to the tank, which is held at a temperature of from about 70 to about 75 C, and in which a CO. . Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. It is found in wheat, rye, and barley.It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners. 0000002198 00000 n The Molecular Weight is 110.11 g/mol. - 65.21.225.73. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C 6 H 6 O 2; molecular weight is 110.0. Cite this article. The reservoir opens through a muscle-controlled valve onto a thick-walled reaction chamber. Editor's Rating: A preferred embodiment utilizes encapsulation. You take the cream, put it in a container, take the powder measurement and add it. Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. The Campaign for Safe Cosmetics has also highlighted concerns. Belhachemi, B., Makhlouf, H. & Belhachemi, M.H. You can expect to hear from a technical specialist within 1 business hour. We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. Data 51, 127129 (2006), J. Lim, S. Jang, H. K. Cho, M. S. Shin, H. Kim, J. Chem.
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